Custom Peptides
Cayman Chemical AVN-101hydrochlorIde 10mg
A multimodal receptor antagonist; an antagonist of 5-HT7, 5-HT2C, 5-HT2A, and 5-HT6 receptors (Kis = 0.153, 1.17, 1.56, and 2.04 nM, respectively); selective for these receptors over 5-HT2B, 5-HT5A, 5-HT1A, and 5-HT1B receptors (Kis = 10.6, 20.8, 61, and 720 nM, respectively); an antagonist of α2A-, α2B-, α2C-, α1B-, α1A-, and α1D-adrenergic receptors (Kis = 0.41, 1.77, 3.55, 9.4, 18.9, and 30.2 nM, respectively), as well as histamine H1 and H2 receptors (Kis = 0.58 and 89 nM, respectively); increases the time spent in the open arms of the elevated plus maze in mice at 0.2, 1, and 5 mg/kg; reduces immobility in the forced swim test and prevents scopolamine-induced amnesia in a passive avoidance test in mice at 0.05 mg/kg
Cayman Chemical UCL-TRO-1938 10mg
An allosteric PI3Kα activator; It binds to PI3Kα in an SPR assay (Kd = 36 µM) and induces PI3Kα activation in a cell-free assay at 25 and 50 µM; increases PtdIns-(3,4,5)-P3 and phosphorylated Akt levels in MEFs (EC50s = 5 and 2-4 µM, respectively); increases tissue survival and decreases infarct size in perfused rat hearts; reduces infarct size in a mouse model of LAD coronary artery occlusion-induced ischemia-reperfusion injury at 10 mg/kg; increases the number of motor neurons and innervation of neuromuscular junctions in a rat model of sciatic nerve crush injury
Cayman Chemical CholesTRolPEG 2000BIotIn 10mg
A biotinylated and PEGylated form of cholesterol; has been used as a lipid anchor to immobilize vesicles, liposomes, viral particles, bacteria, or yeast to microfluidic chips; increases phycoerythrin-conjugated streptavidin density on the surface of mesenchymal stem cells greater than sulfo-NHS-LC-biotin at 10 µM
Cayman Chemical DIpsacosIde B 10mg
A triterpenoid saponin with hepatoprotective activity; enhances acetaminophen-induced autophagy and inhibits acetaminophen-induced apoptosis in HepG2 cells at 0.5 µM; increases survival in a mouse model of acetaminophen-induced acute liver failure at 50 mg/kg
Cayman Chemical NGB 2904hydrochlorIde 10mg
A selective dopamine D3 receptor antagonist (Ki = 1.4 nM); attenuates cocaine- and stress-induced reinstatement of drug-seeking behavior in rats
Cayman Chemical 1PalmItoyl2PyrpheophorbId 10mg
A phospholipid-porphyrin conjugate; LNPs containing 1-palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC and encapsulating FAM-labeled siRNA increase cytosolic siRNA levels; 1-palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC-stabilized nanoemulsions loaded with paclitaxel and combined with laser irradiation reduce tumor growth and increase survival in a KB squamous cell carcinoma mouse xenograft model
Cayman Chemical TedIzolId Phosphate 10mg
A prodrug form of tedizolid; reduces vegetation titer in a rabbit model of aortic valve endocarditis caused by MRSA (15 mg/kg); reduces densities of methicillin-susceptible S. aureus and MRSA infection in a mouse model of catheter-related biofilm infection; increases survival in a rabbit model of MRSA necrotizing pneumonia
Cayman Chemical FesoterodInfumarate 10mg
A muscarinic acetylcholine receptor antagonist (Kis = 15.8, 11.2, 12.6, 22.4, and 25.1 nM for human M1-5, respectively); reduces micturition pressure and increases bladder capacity and ICI in conscious female rats when administered at a dose of 0.01 mg/kg; reduces intermicturition pressure and prevents bladder overactivity in a rat model of spinal cord injury-induced overactive bladder
Cayman Chemical CruzaIn-IN-1 10mg
An inhibitor of cruzain (IC50 = 0.2 nM); selective for cruzain over cathepsin L-like protein and cathepsin B-like protease (IC50s = T. brucei (MIC50 = 25 µM)
Cayman Chemical Heptadecnoyl-L-carnItInch 10mg
A long-chain acylcarnitine; levels are increased in dried blood spots from neonates with propionic or methylmalonic acidemias
Cayman Chemical LysIpresInacetate 10mg
A peptide hormone; an agonist of V1A receptors; binds to rat and human V1A receptors (Kis = 1.2 and 10.1 nM, respectively); increases intracellular calcium levels in cultured rat and human aortic cells (Kact = 12 and 20.8 nM, respectively); induces vasoconstriction in isolated mesenteric arteries from normotensive and spontaneously hypertensive rats; has antidiuretic effects in non-anesthetized dwarf pigs
Cayman Chemical TRtIapIn LQtrIfluoroACTAt 10mg
A peptide derivative of tertiapin; inhibits heteromultimeric potassium channels composed of GIRK1 and GIRK4, as well as Kir1.1; suppresses Purkinje cell pause response to a conditional stimulus in ferrets
Cayman Chemical TrIcIrIbIn Phosphate 10mg
An Akt activation inhibitor and active metabolite of triciribine; binds to the PH domain of Akt and prevents its recruitment to the plasma membrane in MDA-MB-468 cells; reduces the proliferation of A1847 and A2780 cells (IC50s = 1.6 and 18 µM, respectively); inhibits HIV-1 reverse transcriptase activity in CEM-SS cells (IC50 = 0.04 µM), as well as HSV-1 replication in BS-C-1 cells and human CMV plaque formation in HFF-1 IRR cells (IC50s = 20 and 0.8 µM, respectively)
Cayman Chemical BGJ398phosphate 10mg
A pan FGFR inhibitor (IC50s = 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively); suppresses proliferation of cancer cells with wild-type FGFR3 overexpression (IC50s = 5, 30, 32, and 15 nM, for RT112, RT4, SW780, and JMSU1 cells, respectively); inhibited tumor growth in an RT112 bladder cancer xenograft mouse model overexpressing wild-type FGFR3 at 10-30 mg/kg